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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name 20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand
Phytochemical Name 20(s)-ginsenoside Rh2 (PubChem CID: 119307 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 206
Ref_1
Pair Name 20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression CASP3 hsa836
Down-regulation Cleavage CASP8 hsa841
Down-regulation Cleavage PARP1 hsa142
Up-regulation Expression TNFRSF10B hsa8795
Down-regulation Expression XIAP hsa331
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
OV2944-LM-3 Malignant ovarian neoplasm Mus musculus (Mouse) CVCL_E956
L-02 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_6926
In Vivo Model Human hepatocellular carcinoma cells HepG2 (5×10⁵) in the log phase were implanted subcutaneously (s.c.) in the flanks of mice.
Result Our study indicates that Rh2 may act as a sensitizer in combination with TRAIL to increase the efficacy of its anti-tumor activity.
03. Reference
No. Title Href
1 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells. Med Oncol. 2022 May 15;39(5):70. doi: 10.1007/s12032-022-01663-6. Click
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